When you step forward, short cutscene shows the layout of the area. One of the tanks bursts open releasing a creepy, clawed mutant.
OVERVIEW (tactics to follow): In addition to the first humanoid mutant (1). A second identical mutant (2) spawns in the far right corner. Their long, knife-like claws can poison Lara. They can also splash venom. When you kill the first of these mutants, 9 giant pill bug-like creatures (3-11) enter through the chutes along the side walls (shown below). They emerge three at a time, so you don't have to fight them all at once, but even so, they're formidable for their size. Their bite is venomous, and they can spit toxic pink liquid, roll up and down stairs and slopes, and launch themselves into the air for short distances. It's possible to avoid all enemies in this room. But if you want the "Unnatural Selection" achievement/trophy, you must destroy them all.
NOTE: See the footnote in the main walkthrough for tips on completing this area with no kills.
As soon as the cutscene ends, descend to the floor...
...and run forward along either side of the two rows of tanks. Equip your weapon of choice. (I like the Mag Vega here, since you'll soon get more ammo for it.)
Shoot the 2 humanoid mutants from a slight distance so they can't slice or poison Lara. (They'll most likely approach along the path you're on, but depending on how quickly you rush them, one may approach from among the tanks or move around behind you.)
Try to backflip away if they get close. You want to avoid their venomous claws...
...and the purple liquid they splash at Lara. Use an antidote or large health pack if necessary.
When you kill the mutant that burst out of the tank, the first 3 pill bug mutants emerge from the chutes above.
They also have venomous bites and spit pink sludge that inflicts poison. So try to keep your distance and shoot them quickly. Remember to press Roll to change targets when Lara stubbornly aims at the wrong enemy.
When you kill the first three bugs, three more emerge. When you kill them, three more. If there's a lag, look for a bug stuck somewhere out of sight. Occasionally they'll get hung up and just roll in place. You may need to approach to get them un-stuck.
If you need a break, climb on one of the square newel posts at the bottom of each stone staircase.
Then activate Walk so Lara doesn't step off. The bugs can't reach Lara here, and their poison attacks will only rarely splash her. If you like, you can run through your less powerful ammo, like the Rigg 09, though it will take a lot of time and bullets to kill the bugs this way.
To avoid wasting ammo, make sure your shots are connecting. You'll see green hemolymph spurting out when you're doing damage.
Check your Statistics. When you've destroyed all 11 mutants (2 humanoid, 9 bugs), the fight is over; however, the "Unnatural Selection" achievement/trophy won't actually unlock until you finish the level.
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